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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeCTGN
Method

Fluorescence in situ hybridization (FISH) is a technique in which DNA probes, labelled with different coloured fluorescent tags, are applied to cells on a glass slide, in order to visualize one or more specific regions of the genome.

FISH can either be performed on metaphase chromosomes or interphase nuclei.

Diagnostic Use / Indications
  • FISH has many applications and is particularly useful for: 
  • Family follow-up testing of well-recognised microdeletion syndromes, eg. 22q11 deletion (TUPLE1) Williams syndrome ELN).
  • Sex determination studies, eg. neonates with ambiguous genitalia, disorders of sexual development.  Probes routinely applied: SRY (Yp) and X centromere. Other probes available, contact lab to discuss
  • Rapid screening of neonates for trisomy 21 (or other aneuploidy)
  • Haematological studies for specific rearrangements.
  • Discuss with laboratory for further advice
External Price$0.00(Exclusive of GST)
  

Specimen Collection

 
Specimen Collection Protocols

Non-paediatric: 3-5 ml  lithium heparin (green-top tube) peripheral blood, well-mixed

Paediatric or difficult bleed: 1ml lithium heparin (2 paediatric green-top tubes) peripheral blood, well-mixed

Clotted blood unacceptable

Patient Specimen3-5ml peripheral blood (lithium heparin)
Paediatric Specimen1ml peripheral blood (lithium heparin)
Sample Delivery to LabRoom temperature
  

Instructions for Referral to CHLabs

 
Aliquot InstructionsRoom temperature or refrigerated
Aliquot Transport to CHLDo not spin or separate this sample
  

CHLabs Laboratory

 
DepartmentHaematology - Cytogenetics
Contact Details Email Email
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Contact Phone Number03 364 1425
Test AvailabilityTesting is usually performed 3-4 times a week
Turnaround TimeUrgent within 5 days; Non-urgent: within 18 days
Interpretation

 Comment within the report

Uncertainty of Measurement

FISH analysis targets specific chromosomal regions.

The probes used in the test will only detect rearrangements of and enumerate the specific chromosome regions they encompass.

 

Additional Information

If required, please contact this laboratory for further information. 

Delphic Number Test Number5445

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