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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeCTGN
Method

Fluorescent in situ hybridisation (FISH) on formalin fixed paraffin embedded (FFPE) tissue.

Tests available:

MYC Rearrangement

IGH/MYC gene fusion

BCL2 Rearrangement
BCL6 Rearrangement
IGH/BCL2 gene fusion

These same probes may be applied to a standard blood or bone marrow preparation if required. See 'Haematological and Oncological FISH' or click on the link below for details.

http://www.labnet.health.nz/testmanager/index.php?fuseaction=main.DisplayTest&testid=810

Diagnostic Use / Indications

High-grade B-cell Lymphomas were redefined into two distinct categories in the 2017 WHO classification of Tumours and Haematopoietic and Lymphoid Tissues.

The first category, High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, encompasses all B-cell lymphomas that have MYC rearrangement in combination with a BCL2 and/or BCL6 rearrangement.
The second category, High-grade B cell lymphoma, NOS, lack the double or triple hit.
External Price$0.00(Exclusive of GST)
  

Specimen Collection

 
Pre-Testing Requirements

Please call ahead if there is a particular urgency for a result

Specimen Collection Protocols

Only tissue preserved in neutral buffered formalin and paraffin embedded is suitable for use. . NB: Samples de-calcified in formic acid are not suitable for FISH as this process affects the integrity of the DNA

Tissue specimens should be cut into sections of 2-4µm, on poly-L-lysine slides.

Ensure one H&E slide and 5~8 unprocessed slides are supplied.

Slide must be clearly labelled with two patient identifiers, matching those on the request form.

The H&E slide must be assessed by a pathologist prior to receipt, and appropriate areas for FISH analysis should be clearly marked.

Patient SpecimenFormalin fixed paraffin embedded tissue slides
Sample Delivery to LabIn slide-holders or boxes, at ambient temperature
  

CHLabs Laboratory

 
DepartmentHaematology - Cytogenetics
Contact Details Email Email
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Contact Phone Number03 3786 007 ext 86007
Test AvailabilitySamples are processed at least 3 times per week, dependant on sample volume
Turnaround Time1-5 days
Interpretation

Clinically significant rearrangements and copy number changes outside of established normal ranges will be reported with relevant interpretive comment.

Additional Information

 

 

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