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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeMONC
Method

The Idylla MSI Test detects a novel panel of seven monomorphic biomarkers.  Each biomarker is scored for mutation status and results are combined for an overall sample microsatellite instability status as follows: 

Microsatellite Stable (MSS)                 <  2 biomarkers with a ‘Mutation detected’ call 

Microsatellite Instability-High (MSI-H)   ³  2 biomarkers with a ‘Mutation detected’ call

Invalid Result                                    ³  3 biomarkers with an ‘Invalid’ call

The Idylla MSI Test has a Limit of Detection (LOD) of 10% mutant alleles in MSI-H samples.  Samples with <10% mutant alleles are below the LOD, and may not be identified as MSI-H.

Diagnostic Use / Indications

Colorectal cancer patients.

External PriceContact Canterbury Health Laboratories on +64 3 364 0484 or email Labinfo.
  

Specimen Collection

 
Specimen Collection Protocols

6x 5-micron unstained FFPET slides (non-adhesive/uncharged preferred) PLUS 1x H&E stained slide with the tumour area marked (minimum 20% tumour content is required).

Patient SpecimenFFPET - as above.
  

CHLabs Laboratory

 
DepartmentBiochemistry - Molecular Oncology
Contact Details Email Email
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Contact Phone Number03 3786 008 / x86008
Turnaround Time5 working days from receipt of specimen in the laboratory.
Interpretation

The presence of microsatellite instability is consistent with the loss of expression of MLH1 and PMS2 by immunohistochemistry.  In the context of a family history suggestive of Hereditary Non-polyposis Colorectal Cancer, it is an indication for genetic analysis of one or more mismatch repair genes.  Such analysis is not indicated if the sample is microsatellite stable.


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