IgG subclasses

Test Identifier Information
Registration Code	SUBC
Method	Endpoint nephelometry
External Price	$201.82(Exclusive of GST)

Specimen Collection
Specimen Collection Protocols	None
Patient Specimen	5 mL clotted blood
Paediatric Specimen	2 mL clotted blood
Sample Delivery to Lab	Room temperature

Instructions for Referral to CHLabs
Aliquot Instructions	600 uL serum - minimum 1 mL serum - preferred Store in fridge
Aliquot Transport to CHL	Room temperature

CHLabs Laboratory
Department	Biochemistry - Immunology
Contact Details	Email This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
Contact Phone Number	(03) 364 0414 \| x80414
Test Availability	Batched at least monthly
Turnaround Time	4 weeks
Reference Interval	Contact laboratory as age related reference ranges apply
Interpretation	IgG Subclasses Quantitation of individual immunoglobulin classes and subclasses is necessary to reveal certain immune deficiency states. Numerous diseases and symptoms have been associated with deficiency of one or more of the IgG subclasses - recurrent respiratory tract infections, GI symptoms (diarrhoea etc.), atopy, multi system diseases and autoimmunity, neurologic disorders, AIDS and other immunodeficiences. However used in isolation IgG subclasses deficiency has very limited clinical utility. The four subclasses of IgG are distinct in terms of structure and function, and levels in serum. Functional differences occur in relation to complement activation and activation of various immune cells. Furthermore, antibody responses to antigenic stimulation tend to be limited to one or more subclasses. Protein antigens of bacteria, viruses, vaccines, and food, tend to elicit an IgG1 and IgG3 antibody response. Carbohydrate (eg pneumovax 23, Hib vaccine) antigens tend to elicit IgG2 and IgG4 antibody response.
Delphic Number Test Number	7131