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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeSLAA
Method

Line blot.

External Price$114.48(Exclusive of GST)
  

Specimen Collection

 
Patient Specimen5 mL clotted blood (Red)
Paediatric Specimen0.5 mL clotted blood (Red)
Sample Delivery to LabRoom temperature
  

Instructions for Referral to CHLabs

 
Aliquot Instructions200 uL serum (minimun) 1 mL serum (preferred)
Aliquot Transport to CHLRoom temperature
  

CHLabs Laboratory

 
DepartmentBiochemistry - Immunology
Contact Details Email Email
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Contact Phone Number(03) 364 0414 | x80414
Test AvailabilityMon - Fri, business hours only
Turnaround Time3-4 weeks but contact the laboratory if the test is urgent.
Reference Interval

Not detected and positive.

Interpretation

Soluble Liver Antibodies

Autoimmune hepatitis (AIH) is a rare chronic liver diesase of unknown etiology. The estimated prevalence of AIH in Northern European countries is approximately 160-170 patients/106 inhabitants. The disease predominates among women and is characterised by hypergammaglobulinaemia even in the absence of cirrhosis, characteristic autoantibodies, association with HLA DR3 or DR4 and a favourable response to immunosuppressive treatement.

The onset of AIH disease is usually insidious, with unspecific syptoms such as fatigue, malaise, arthralgias and fluctuating jaundice, right upper quadrant pain and lethargy. However a substantial proportion of patients may have no obvious signs or symptoms of liver disease while occasionally the presentation may be severe and almost identical to an acute or fulminant episode of viral hepatitis.

The archtypical AIH patient was believed to be a young female with endocrine abnormalities, there is increasing evidence that the disease can also affect males and present at almost any age (the large majority of patients being between 50 and 70 years of age.)

Although the presence of autoantibodies is one of the distinguishing features of AIH there is no single autoantibody with the diagnostic specificity that antimitochondrial autoantibodies (AMA) demonstrate for the diagnosis of primary biliary cirrhosis (PBC). It is rather a diagnosis reached by exclusion of other factors leading to chronic hepatitis that includes viral, toxic, genetic and metabolic causes.

 

Classification of Autoimmune Hepatitis (AIH) According to Autoantibodies Detection:

Type of AIH:

 

Characteristic autoantibodies:

AIH-1

 

ANA, SMA, p-ANCA anti-A SGP-R, anti-SLA/LP

AIH-2

 

anti-LKM-1, anti-LKM3, anti-LC1, anti-ASGP-R

Additional Information

Test includes M2 (pyruvate-dehydrogenase-complex), LKM-1 (liver-kidney microsomes, cytochrome P450 II D6), LC-1 (cytosolic liver antigen type 1; formiminotransferase-cyclodeaminase) and SLA/LP (soluble liver antigen/liver pancreas antigen), Sp 100, gp210 and Ro52

Delphic Number Test Number7561

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