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Test Identifier Information

 
Registration CodeTPGS
Method

PCR using sequence-specific FRET hybridization probes (hyb-probes) to detect the Factor V Leiden (F5:c.1691G>A) and Prothrombin (F2:c.20210G>A) mutations.

Diagnostic Use / Indications

The presence of either the Factor V Leiden or Prothrombin c.20210G>A variants in the heterozygous state is a risk factor for thrombosis, including deep vein thrombosis (DVT), and have also been associated with recurrent pregnancy loss.

There is a reported association between oral contraceptive use, the prothrombin c.20210G>A variant, and cerebrovascular events, so genotyping may be indicated before initiation of oral contraception.

Reduced activated protein-C ratio (APCR) may indicate presence of the FVL variant (normal - APCR >2.1, heterozygous FVL - APCR 1.5-1.8, homozygous FVL - APCR <1.5).

External Price$196.06(Exclusive of GST)
  

Specimen Collection

 
Patient Specimen4.0mL EDTA,
Paediatric Specimen0.5 mL - 1 mL EDTA blood
Sample Delivery to LabAmbient
  

CHLabs Laboratory

 
DepartmentBiochemistry - Molecular Pathology
Contact Details Email Email
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Contact Phone Number03 3640 548
Test Availability9am to 5pm, Monday to Friday
Turnaround TimeWithin 4 weeks
Interpretation

Heterozygosity for either the FVL or prothombin c.20210G>A variants indicates a 2-3 fold increased risk of thrombosis.

Compound heterozygosity, or homozygosity for either variants, is associated with an appreciable thrombotic risk and such patients may require ongoing clincal care.

Additional Information
  1. This genetic test needs nucleated cells. Please don’t centrifuge or freeze the EDTA blood tube.
  2. Genomic DNA must be extracted from the specimen prior to testing. This incurs an additional charge (see GDNA). Laboratories may prefer to submit DNA for testing. Please provide a minimum of 5 micrograms of DNA at 20 nanograms / microlitre.
  3. If storing blood tube prior to delivery please refrigerate at 4 degrees (transport still at ambient temperature).

Delphic Number Test Number4589

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