Procollagen type 3 aminoterminal peptide, Serum
Test Identifier Information | |
| Registration Code | PNP |
| Method | RIA-Uniq P3NP Orion Diagnostica kit |
| Diagnostic Use / Indications | Screening for methotrexate-induced liver fibrosis in patients with skin disease e.g., psoriasis. P3 NP is not organ specific and does not reflect earlier liver damage - it reflects fibrogenesis. A study published in the British Journal of Dermatology (2001:143;100-103), concluded that as long as P3 NP was consistently normal in serial investigations there was minimal risk of developing substantial hepatic necrosis. |
| External Price | $66.74(Exclusive of GST) |
Specimen Collection | |
| Patient Specimen | Clotted blood(Red), Serum only |
| Paediatric Specimen | 0.5 mL serum (Red) |
| Sample Delivery to Lab | Ambient |
Instructions for Referral to CHLabs | |
| Aliquot Instructions | 1 mL serum separate within 1-2 hrs Only Serum, other sample types are unsuitable |
| Aliquot Transport to CHL | frozen |
CHLabs Laboratory | |
| Department | Biochemistry - Specialist |
| Contact Details |
Email
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| Contact Phone Number | 03 364 0326 x 80326 |
| Test Availability | Performed as a batch of 40 samples |
| Turnaround Time | 1-3 weeks |
| Reference Interval | Ref range 2.3 - 6.4 ug/L |
| Interpretation | According to the Manchester protocol (Br J Derm 2005; 152:444-50), P3NP should be monitored every 2-3 months during continued methotrexate treatment. Considerations for liver biopsy include P3NP above 8.0 ug/L on the pre-treatment sample or on two consecutive samples or P3NP above 4.2 ug/L in at least three samples over a 12 month period. Note that P3NP is a marker of scar formation and transient elevations may be seen with acute tissue damage ( recommend follow up after 3 months) or persistently in other chronic fibrotic conditions ( eg myelofibrosis). It is not intended for use in non-adults.
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| Delphic Number Test Number | 4758 |
