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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodePRAL
Method

As a stand alone PREALBUMIN test

End-point Nephelometry: - Latex particles are coated with protein specific anti-human antibodies (e.g. anti-Prealbumin) forming antigen:antibody complexes, when exposed to serum containing that specific protein. The latex particles improve sensitivity by increasing the turbidity of the antigen:antibody complex in solution. Quantitative nephelomtric measurement of the turbidity is proportional to the concentration of the protein in the serum. Serum protein concentrations can then be calculated by comparing the turbidity to that of a known standard. 

As part of the Serum Protein Profile (SPE)

Electrophoresis: - The separation of proteins, using an electric field, on the basis of native protein charge density.

Immunoelectrophoresis: - The electrophoretic separation of proteins in an anti-sera impregnated gel, resulting in quantitative identification of specific proteins.

Diagnostic Use / Indications

Prealbumin is a short term indicator of protein nutritional status (especially in premature infants, cancer or surgical patients).

Prealbumin is also a negative acute phase reactant. Synthesis of prealbumin may be decreased resuting in a fall of prealbumin in serum in the following situations:

  • Inflammation
  • Malignancy
  • Cirrhosis of the liver
  • Potein losing gastro-enteropathies
  • Malnutrition

 

External Price$40.72(Exclusive of GST)
  

Specimen Collection

 
Specimen Collection Protocols

Allow specimen to clot completely at room temperature.

Spin down and separate serum (or plasma) from cells as soon as possible.

Haemolysed samples are not acceptable.

Patient SpecimenBlood 5-10 mL Plain(Red),Heparin(Green).
Paediatric SpecimenBlood 0.2 mL Plain(Red),Heparin(Green)
  

Instructions for Referral to CHLabs

 
Aliquot InstructionsMinimum 200 μL; Preferred >0.5 mL serum (preferred) or plasma; Refrigerate
Aliquot Transport to CHLOn ice or ambient
  

CHLabs Laboratory

 
DepartmentBiochemistry - Protein Laboratory
Contact Details Email Email
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Contact Phone Number(03)3640334 | x80334
Test AvailabilityMonday to Friday, 8.00 am - 5.00 pm
Turnaround Time1 - 3 days
Reference Interval
Age*Concentration g/L
  
Adult0.2-0.3

*Prealbumin levels are age dependent.

Below the normal level there is an increasing gradient of severity.

Interpretation

A low serum prealbumin may indicate a failure of the hepatic synthesis of the protein, which may result from:

  • malnutrition
  • inflammation
  • hepatic injury
  • protein losing gastro-enteropathies

The short half-life of prealbumin (2-2.5 days) makes it a useful inidicator for monitoring nutritional status, especially when parenteral nutrition is being administered.

Prealbumin is not affected by hydration status.

Additional Information

Prealbumin data sheet

Refer to Biochemistry - Protein Laboratory Ext 80334

Delphic Number Test Number3221

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