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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeSB2
Method

End-point Nephelometry: - Polystyrene particles coated with specific antibodies to human beta 2 microglobulin are aggregated when mixed with samples containing human beta 2 microglobulin.  These aggregates scatter a beam of light passed through the sample.  The intensity of the scattered light is proportional to the concentration of the beta 2 microglobulin in the sample.  The result is evaluated by comparison with a standard of known concentration.

Diagnostic Use / Indications

Beta 2 microglobulin is a small membrane protein (11,800 Dalton) associated with the heavy chains of class I major histocompatibility complex proteins and is, therefore on the surface of all nucleated cells.  The small size allows beta 2 microglobulin to pass through the glomerular membrane, but it is almost completely reabsorbed in the proximal tubules.  

Serum beta 2 microglobulin levels are elevated in diseases associated with increased cell turnover.  Levels are also elevated in several benign conditions such as chronic inflammation, liver disease, renal dysfunction, some acute viral infections, and a number of malignancies, especially haematologic malignancies associated with the B-lymphocyte lineage.

External Price$31.77(Exclusive of GST)
  

Specimen Collection

 
Patient Specimen4.0mL Red Top, Heparin (green), or EDTA (purple)
Paediatric SpecimenBlood 1.5 mL Plain (Red)
  

Instructions for Referral to CHLabs

 
Aliquot Instructions0.5 mL
Aliquot Transport to CHLAmbient
  

CHLabs Laboratory

 
DepartmentBiochemistry - Protein Laboratory
Contact Details Email Email
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Contact Phone Number(03)3640334 | x80334
Test AvailabilityTuesday, Thursday and Friday. 8.00 am - 4.00 pm
Turnaround Time1-3 days
Reference Interval
Age (Yrs)Minimum (mg/L)Maximum (mg/L)
< 601.02.5
> 601.03.5

 

Interpretation

A serum beta 2 microglobulin < 4 mg/L is a good prognostic factor in patients with multiple myeloma.

Additional Information

 

 

Delphic Number Test Number6752

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