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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeCDT
Method

Capillary Electrophoresis

Diagnostic Use / Indications

Carbohydrate deficient transferrin (CDT)can be used to assess a patient's chronic alcohol consumption. The test does not correlate with the amount of alcohol consumed, but relates to the prolonged consumption of large quantities of alcohol. A single episode of heavy drinking will not elevate CDT levels.

CDT is reported as a percentage of total transferrin to reduce the effects of gender and varying transferrin concentrations.

Note: 95% of non-drinkers and individuals with normal drinking patternss, have a %CDT of < 1.8%. Values > 1.8 % usually indicate a consumption of more than 60 g of ethanol per day over a period of at least one week.  5% of individuals will therefore have a %CDT of > 1.8 % without excessive drinking.

CDT has a long half-life of 15 days. Under conditions of total abstinence it may take 1-2 months for %CDT levels to return to normal.

The most reliable interpretation is obtained with a series of % CDT tests to detect trends, with the tests being performed at 1-2 month intervals to allow for the long half-life of this protein.

False positive  % CDT results may occur in patients with severe liver disease, autoimmune hepatitis, biliary cirrhosis, liver cell cancer, haemochromatosis, genetic transferrin variants and the rare CDG syndrome.

External Price$75.00(Exclusive of GST)
  

Specimen Collection

 
Patient SpecimenPlain(Red) 5 - 10 mL (T15)
Sample Delivery to LabRefrigerated (preferred) or ambient.
  

Instructions for Referral to CHLabs

 
Aliquot InstructionsMinimum 250 uL, Preferred 500 uL serum. Plasma is NOT acceptable.
Aliquot Transport to CHLRefrigerated (preferred) or ambient.
  

CHLabs Laboratory

 
DepartmentBiochemistry - Protein Laboratory
Contact Details Email Email
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Contact Phone Number(03)3640334 | x80334
Test AvailabilityBatched weekly
Turnaround Time1 week
Reference Interval
Reference Interval      Classification     
< 1.8 %Normal result
1.8 - 2.0 %Inconclusive
> 2.0 %Positive result

 

 

Interpretation

A CDT value of > 2.0 % is suggestive of chronic alcohol consumption.  It is strongly recommended that results be corroborated with other evidence of excessive alcohol consumption. 

Uncertainty of Measurement

10 %

Additional Information

For inborn errors of metabolism or assessment of transferrin variants in neonates (i.e. Carbohydrate deficient glycosylation, CDG) refer to Paediatric Biochemistry (03 364 0300 extension 80118).

Delphic Number Test Number7448

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