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Test Identifier Information

 
Registration CodeTOX
Method

HPLC

External Price$37.18(Exclusive of GST)
  

Specimen Collection

 
Specimen Collection Protocols

 Do NOT use gel tubes or EDTA tubes for this assay

 

Patient Specimen 4.0mL Red Top or Heparin (Green)
Sample Delivery to LabAmbient or on ice
  

Instructions for Referral to CHLabs

 
Aliquot Instructions2 mL Plasma or Serum Fridge or freezer
Aliquot Transport to CHLOn ice or ambient
  

CHLabs Laboratory

 
DepartmentBiochemistry - Toxicology
Contact Details Email Email
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Contact Phone Number(03) 364 0322 | x80322
Test AvailabilityMonday, Wednesday and Fridays.
Turnaround Time2 - 4 days
Reference Interval

Reference Range 1000 - 2000 nmol/L.

 

Additional Information

Specimen must be collected pre-dose or at least 10- 15 hours after the last dose of clozapine.

While there is little evidence that doses need to be individualised based on plasma drug concentrations plasma levels may be useful in the case of possible drug interaction, overdose or lack of response with usual doses without evidence of toxicity.

The incidence of CNS side effects and seizures increases at concentrations over 2000 nmol/L and increases further over 3000 nmol/L.

Drugs that decrease clozapine concentration incude phenytoin, carbamazepine and valproate and probably include rifampicin, phenobarbitone and tobacco smoke.

Drugs that increase clozapine concentration include cimetidine, fluvoxamine, erythromycin anf fluoxetine and probably include azole antifungal agents and diltiazem.

Delphic Number Test Number4666

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