Test Identifier Information
Two-site immunometric assay on Beckman Coulter ACCESS analyzer
|Diagnostic Use / Indications|
Investigation of galactorrhoea.
Investigation of amenorrhoea, infertility or hypogonadism. Raised prolactin levels are (often without galactorrhoea) associated with impaired gonadal function.
Differential diagnosis of pituitary fossa enlargement. Many "non-functioning" pituitary tumours in males and females are prolactin-secreting adenomas. Prolactin estimations are important in assessing the response to pituitary surgery, radiotherapy and drugs such as bromocriptine or cabergoline.
Assessment of hypothalamic-pituitary function. Basal prolactin concentrations may be raised in some patients with hypothalamic disorders such as craniopharyngioma. TRH and chlorpromazine stimulation have been used to further demonstrate abnormalities in prolactin secretion. The results are variable, and these tests are not recommended as a routine.
|External Price||$19.24(Exclusive of GST)|
Patient should be unstressed but need not be fasting. Morning samples preferred. Because prolactin secretion is pulsatile, it is often desirable to take three samples at 20 minute intervals.
It is essential to state the medication that the patient is receiving, especially phenothiazine derivatives, aldomet, metoclopramide and oral contraceptive preparations etc.
A statement of the menstrual history and presence or absence of galactorrhoea is also necessary.
|Specimen Collection Protocols|
Serum or Li heparin
|Patient Specimen||Blood, 4 mL tube, Red or Green top.|
|Sample Delivery to Lab||<22 degrees C within 3 days|
Instructions for Referral to CHLabs
|Aliquot Instructions||Preferably >0.8 mL. Minimum 0.4 mL|
|Aliquot Transport to CHL||Ambient or cold within 3 days|
|Contact Phone Number||(03) 364 0848 l x80848|
|Test Availability||Mon - Fri, business hours only|
|Turnaround Time||1 - 4 days|
Female: 50 - 550 mIU/L
Changes in prolactin levels may occur seasonally (highest in spring) and across the day (circadian rhythm); nocturnal surges have been reported.
|Uncertainty of Measurement|
+/-6mIU/L at <100mIU/L
5.9% at >100mIU/L
Serum or lithium heparin plasma is preferred because the results on samples collected in full EDTA tubes may be up to 5% lower than for serum.
|Delphic Number Test Number||6549|