skip navigation
A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodePRL
Method

Two-site immunometric assay on Beckman Coulter ACCESS analyzer

Diagnostic Use / Indications

 

Investigation of galactorrhoea.

Investigation of amenorrhoea, infertility or hypogonadism. Raised prolactin levels are (often without galactorrhoea) associated with impaired gonadal function.

Differential diagnosis of pituitary fossa enlargement. Many "non-functioning" pituitary tumours in males and females are prolactin-secreting adenomas. Prolactin estimations are important in assessing the response to pituitary surgery, radiotherapy and drugs such as bromocriptine or cabergoline.

Assessment of hypothalamic-pituitary function. Basal prolactin concentrations may be raised in some patients with hypothalamic disorders such as craniopharyngioma. TRH and chlorpromazine stimulation have been used to further demonstrate abnormalities in prolactin secretion. The results are variable, and these tests are not recommended as a routine.

External Price$18.85(Exclusive of GST)
  

Specimen Collection

 
Pre-Testing Requirements

Patient should be unstressed but need not be fasting. Morning samples preferred. Because prolactin secretion is pulsatile, it is often desirable to take three samples at 20 minute intervals.

It is essential to state the medication that the patient is receiving, especially phenothiazine derivatives, aldomet, metoclopramide and oral contraceptive preparations etc.

A statement of the menstrual history and presence of absence or galactorrhoea is also necessary.

Specimen Collection Protocols

Serum or Li heparin

Patient SpecimenBlood, 4 mL tube, Red or Green top.
Sample Delivery to Lab<22 degrees C within 3 days
  

Instructions for Referral to CHLabs

 
Aliquot InstructionsPreferably >0.8 mL. Minimum 0.4 mL
Aliquot Transport to CHLAmbient or cold within 3 days
  

CHLabs Laboratory

 
DepartmentEndocrinology Laboratory
Contact Details Email Email
This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
Contact Phone Number(03) 364 0848 | x 80848
Test AvailabilityMon - Fri, business hours only
Turnaround Time1 - 4 days
Reference Interval

Female: 50 - 550 mIU/L
Male: 50 - 350 mIU/L

Interpretation

Refer to Hyperprolactinaemia and Macroprolactin Information.

Changes in prolactin levels may occur seasonally (highest in spring) and across the day (circadian rhythm); nocturnal surges have been reported.

Additional Information

Serum or lithium heparin plasma is preferred because the results on samples collected in full EDTA tubes may be up to 5% lower than for serum.
WARNING: Incomplete filling of EDTA tubes will cause gross underestimation of prolactin levels.

Delphic Number Test Number6549

CHL Follow us on Facebook