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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeTG
Method

Beckman Coulter Access

Diagnostic Use / Indications

Post-operative monitoring in differentiated thyroid carcinoma (DTC).

See also Thyroglobulin: applications and interpretation

External Price$33.99(Exclusive of GST)
  

Specimen Collection

 
Pre-Testing Requirements

Take samples pre or >2 wks post any fine needle aspiration.

Patients who are undergoing biotin therapy and/or ingesting biotin supplements with levels of >100ng/mL will show a falsely low Thyroglobulin result in the Beckman Thyroglobulin assay.

Specimen Collection Protocols

Serum only

Patient SpecimenBlood 2 mL. Red top.
  

Instructions for Referral to CHLabs

 
Aliquot Instructions>0.5 mL.
Aliquot Transport to CHLAmbient up to 8 hrs otherwise cold/frozen
  

CHLabs Laboratory

 
DepartmentEndocrinology Laboratory
Contact Details Email Email
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Contact Phone Number (03) 364 0848 l x80848
Test AvailabilityBatched twice weekly - urgent testing by arrangement
Turnaround Time1 - 4 days
Reference Interval

<0.1 - 58 µg/L in serum

Interpretation

Serum thyroglobulin should be undetectable (<0.1 µg/L) in a patient who has had a total thyroidectomy and has a TSH <0.1 mIU/L.

Anti-thyroglobulin antibodies (TgAb), even at low titre, may interfere with thyroglobulin measurement to cause falsely low or undetectable Tg levels.

In July 2011 the TgAb test method changed to the Roche Elecsys/Cobas method on the Roche E411 from the Beckman ACCESS method. Subsequent values will usually not be comparable to earlier values and a consequently a new TgAb baseline should be established where appropriate.

There is evidence in patients with DTC that an increase in serum TgAb on serial sampling is a risk factor for disease recurrence.

 See also Thyroglobulin: applications and interpretation

Uncertainty of Measurement

+/- 0.1 µg/L for < 0.91 µg/L,

11.0% for > 0.91 µg/L.

Additional Information

1. Test includes a screen for potentially interfering Tg autoantibodies (TgAb). 

In July 2011 the TgAb test method changed to the Roche Elecsys/Cobas method from the Beckman ACCESS method. Subsequent values will usually not be comparable to earlier values and a consequently a new baseline should be established where appropriate.

2. Serum is the recommended specimen, although serum or lithium heparin plasma may be used for Tg measurement, lithium heparin is not suitable for TgAb test.

Delphic Number Test Number6580

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