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Test Identifier Information

 
Registration CodeMONC
Method

PCR followed by EcoRV restriction enzyme digest.

Diagnostic Use / Indications

The two most frequent FLT3 mutations associated with cytogenetically normal AML (CN-AML) are FLT3-ITD mutations in approximately 30% of patients and nucleotide substitutions, deletions, or insertions involving the D835/I836 residues of the second tyrosine kinase domain (i.e. FLT3-TKD) in approximately 7% CN-AML patients (Yamamoto et al., 2001; review: Mrozek et al, 2007).   Point mutations of codons 835/836 have also been found in infant and childhood acute lymphoblastic leukaemia (ALL), especially in the setting of mixed lineage leukaemia (MLL) gene rearrangement and T-ALL.

External Price$303.45(Exclusive of GST)
  

Specimen Collection

 
Pre-Testing Requirements

Nil

Specimen Collection Protocols

Aseptic technique.

Patient Specimen2-5 mL EDTA blood or 1 mL bone marrow aspirate.
Paediatric Specimen0.5 ml
Sample Delivery to LabWithin 48 hours of collection.
  

Instructions for Referral to CHLabs

 
Aliquot Instructions2-5 ml EDTA blood or 1 ml bone marrow.
  

CHLabs Laboratory

 
DepartmentBiochemistry - Molecular Oncology
Contact Details Email Email
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Contact Phone Number03 3786 008 / x86008
Turnaround Time10 days (urgent processing upon request).
Delphic Number Test Number8263

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