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Test Identifier Information

Registration CodeNIPS

This test is not Ministry of Health funded. The patient pays for this test.

Contact either  Julia Woods or Melanie Green (03) 364 0122 x 80122

Diagnostic Use / Indications

NIPS is a highly sensitive and specific screening test for Trisomy 21 (Down Syndrome), Trisomy 18 (Edward Syndrome) and Trisomy 13 (Patau Syndrome) performed on a sample of maternal blood. The test can be performed from the 10th week of gestation.

Testing can be performed in singleton and twin pregnancies.

Requests for NIPS are only accepted on a fully completed CHL Request form available from the laboratory.

NIPS is a screening test with a sensitivity of >99% for trisomy 21, trisomy 18 and >85% for trisomy 13. A ‘low risk’ result does not completely exclude fetal chromosomal abnormality. A ‘high risk’ result should be followed up by specialist referral for diagnostic testing.

In about 3% of tests it is not possible to provide a result due to a low concentration of fetal DNA relative to maternal DNA (low fetal fraction) and a ‘No result’ will be issued. The fetal fraction decreases with increasing maternal weight, such that the risk of a ‘No result’ is about 20% in a woman with a maternal weight of 95 kg.

External Price$545.59(Exclusive of GST)

Specimen Collection

Pre-Testing Requirements

Patients & Clinicians must  read & fill out the consent form & request form ( in the below attachments).  Both forms are to be given to the lab when the blood is collected. 

CHL Request Form

Patient information document

Specimen Collection Protocols


Maternal blood collected in a 10 ml Streck BCT tube. The tube must have 7 mL of blood. The tube must be gently inverted 10 times after blood sampling. Whole blood required do not spin, or separate.

This test is not Ministry of Health funded. The patient will have to bear this cost.




Patient Specimen10 mL Streck BCT tube, Must have 7mL of blood
Paediatric SpecimenNA
Sample Delivery to LabKept at room temperature, the tubes should not be frozen. Whole blood required do not spin, or separate

Instructions for Referral to CHLabs

Aliquot InstructionsWhole blood required do not spin, or separate.
Aliquot Transport to CHLNA

CHLabs Laboratory

DepartmentBiochemistry - Antenatal
Contact Details Email Email
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Contact Phone Number(03) 364 0332 | x80332
Test AvailabilityMonday to Friday 7.30 am 5 pm
Turnaround TimeApprox 10 working days from receipt into Australia Lab (approx 3 days transit time)
Referred toSent to the Victorian clinical genetic services, Australia.
Reference Interval

Either ‘LOW RISK’ or ‘HIGH RISK’


This assay is a screening test. False positive and false negative test results can occur. High risk test results require follow up by a specialist obstetrician. Low risk test results are highly accurate for excluding trisomy of chromosome 21,18 and 13 or loss of X or Y chromosomes.

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