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A B C D E F G H I J K L M N O P Q

Test Identifier Information

 
Registration CodeTOX
Method

LCMS following solvent extraction

External Price$84.66(Exclusive of GST)
  

Specimen Collection

 
Specimen Collection Protocols

Samples should be collected at trough, just prior to the next dose.

 

Do NOT use gel tubes for this analysis

Patient Specimen5 mL Heparin(Green) or Plain(Red)
Paediatric Specimen2 mL Heparin(Green)
  

Instructions for Referral to CHLabs

 
Aliquot Instructions0.5 mL heparin plasma (serum OK) Fridge 4C
Aliquot Transport to CHLOn ice
  

CHLabs Laboratory

 
DepartmentBiochemistry - Toxicology
Contact Details Email Email
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Contact Phone Number(03) 364 0322 | x80322
Test AvailabilityFriday with results available late Monday
Turnaround Time1 week
Reference Interval

Plasma perhexaline concentrations should be maintained between 0.15 - 0.60 mg/L.

Additional Information

Perhexaline and its metabolites are cleared from the body via extensive hepatic metabolism and are excreted in the bile and urine. Perhexaline is subject to saturable (non-linear) metabolism so that small changes in dosage can produce disproportionate changes in plasma concentration. Perhexaline is also subject to genetic polymorphism and 5 - 10% of caucasion patients are poor metabolisers achieving high plasma perhexaline concentrations with usual doses.

Because of perhexalines slow and variable clearance, the marked inter-subject variability in metabolism of the medicine and the potential for serious toxicity, regular monitoring of plasma levels of perhexaline is essential commencing at the end of the first week of use.

Delphic Number Test Number4684

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